Wyniki wyszukiwania dla: A. Roy

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Alternatives assessment: An analysis on progress and future needs for research and practice

Aude M. Bechu, Monika A. Roy, Molly Jacobs, Joel A. Tickner

Integrated Environmental Assessment and Management > 20 > 5 > 1337 - 1354

Alternatives assessment is a science‐policy approach to support the informed substitution of chemicals of concern in consumer products and industries, with the intent of avoiding regrettable substitution and facilitating the transition to safer, more sustainable chemicals and products. The field of alternatives assessment has grown steadily in recent decades, particularly after the publication of...

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Pyruvate kinase deficiency in 29 Turkish patients with two novel intronic variants

Veysel Gök, Göksel Leblebisatan, Dilek Gürlek Gökçebay, Salih Güler, więcej

British Journal of Haematology > 205 > 1 > 236 - 242

Pyruvate kinase (PK) is a key enzyme of anaerobic glycolysis. The genetic heterogeneity of PK deficiency (PKD) is high, and over 400 unique variants have been identified. Twenty‐nine patients who had been diagnosed as PKD genetically in seven distinct paediatric haematology departments were evaluated. Fifteen of 23 patients (65.2%) had low PK levels. The PK:hexokinase ratio had 100% sensitivity for...

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Factors affecting feed conversion ratios in US commercial catfish production ponds

Nathan M. Stone, Carole R. Engle, Ganesh Kumar, Menghe H. Li, więcej

Journal of the World Aquaculture Society > 55 > 3 > n/a - n/a

Feed conversion ratio (FCR) is widely used as a measure of feed use efficiency in commercial aquaculture production and research. Surprisingly, little work has focused on the factors that affect FCR in plankton‐based, commercial ponds despite the widespread use of FCR as a production metric. Proposals to use FCR as a numeric standard for environmental regulation (mandatory or voluntary) raise questions...

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Irrigation contrasts through the morning transition

J. K. Brooke, M. J. Best, A. P. Lock, S. R. Osborne, więcej

Quarterly Journal of the Royal Meteorological Society > 150 > 758 > 170 - 194

The Land surface Interactions with the Atmosphere over the Iberian Semi‐arid Environment (LIAISE) campaign was conducted in July 2021, primarily to investigate the role of irrigation in modulating the boundary‐layer evolution in the Catalan region of northeastern Spain. Contrasts in near‐surface meteorological parameters and boundary‐layer thermodynamic profiles at an irrigated and rainfed (arid)...

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Discovery and validation of genes driving drug‐intake and related behavioral traits in mice

Tyler A. Roy, Jason A. Bubier, Price E. Dickson, Troy D. Wilcox, więcej

Genes, Brain and Behavior > 23 > 1 > n/a - n/a

Substance use disorders are heritable disorders characterized by compulsive drug use, the biological mechanisms for which remain largely unknown. Genetic correlations reveal that predisposing drug‐naïve phenotypes, including anxiety, depression, novelty preference and sensation seeking, are predictive of drug‐use phenotypes, thereby implicating shared genetic mechanisms. High‐throughput behavioral...

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Disturbance: a double‐edged sword for restoration in a changing climate

Alejandro Brambila, Paul B. Reed, Scott D. Bridgham, Bitty A. Roy, więcej

Restoration Ecology > 31 > 1 > n/a - n/a

Ecological restoration often relies on disturbance as a tool for establishing target plant communities, but disturbance can be a double‐edged sword, at times initiating invasion and unintended outcomes. Here we test how fire disturbance, designed to enhance restoration seeding success, combines with climate and initial vegetation conditions to shift perennial versus annual grass dominance and overall...

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The Zebrafish (Danio rerio) Embryo Model as a Tool to Assess Drinking Water Treatment Efficacy for Freshwater Impacted by Crude Oil Spill

Monika A. Roy, Aarthi Mohan, Yankel Karasik, John E. Tobiason, więcej

Environmental Toxicology and Chemistry > 41 > 11 > 2822 - 2834

Traditional approaches toward evaluating oil spill mitigation effectiveness in drinking water supplies using analytical chemistry can overlook residual hydrocarbons and treatment byproducts of unknown toxicity. Zebrafish (Danio rerio) were used to address this limitation by evaluating the reduction in toxicity to fish exposed to laboratory solutions of dissolved crude oil constituents treated with...

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Mixed infection of a new begomovirus, Jatropha leaf curl Guntur virus and recombinant/chimeric jatropha leaf curl Gujarat virus in Jatropha gossypiifolia

S. Gireeshbai, S.K. Prabhudas, S.K. Sharma, B. Mandal, więcej

Letters in Applied Microbiology > 75 > 4 > 1000 - 1009

The Jatropha gossypiifolia plant showing the severe leaf curl symptoms grown in the borders of chilli fields in Guntur, Andhra Pradesh, India was collected. The infection of begomovirus was detected using the degenerate primers followed by rolling circle amplification (RCA). The RCA products digested with KpnI and EcoRI showing the unit length of the begomovirus genome were cloned in pUC19 and sequenced...

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The use of next‐generation sequencing in the diagnosis of rare inherited anaemias: A Joint BSH/EHA Good Practice Paper*

Noémi B. A. Roy, Lydie Da Costa, Roberta Russo, Paola Bianchi, więcej

British Journal of Haematology > 198 > 3 > 459 - 477

artykuł

Functional impairment of erythropoiesis in Congenital Dyserythropoietic Anaemia type I arises at the progenitor level

Caroline Scott, Kerol Bartolovic, Sally‐Ann Clark, Dominic Waithe, więcej

British Journal of Haematology > 198 > 1 > e10 - e14

artykuł

Propranolol Promotes Bone Formation and Limits Resorption Through Novel Mechanisms During Anabolic Parathyroid Hormone Treatment in Female C57BL/6J Mice

Annika Treyball, Audrey C. Bergeron, Daniel J. Brooks, Audrie L. Langlais, więcej

Journal of Bone and Mineral Research > 37 > 5 > 954 - 971

Although the nonselective β‐blocker, propranolol, improves bone density with parathyroid hormone (PTH) treatment in mice, the mechanism of this effect is unclear. To address this, we used a combination of in vitro and in vivo approaches to address how propranolol influences bone remodeling in the context of PTH treatment. In female C57BL/6J mice, intermittent PTH and propranolol administration had...

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Expanded eligibility for emerging therapies in sickle cell disease in the UK – crizanlizumab and voxelotor

Sona M. Vora, Stephen Boyd, Nicholas Denny, Elizabeth Jackson, więcej

British Journal of Haematology > 197 > 4 > 502 - 504

artykuł

Technological progress in the US catfish industry

Shraddha Hegde, Ganesh Kumar, Carole Engle, Terry Hanson, więcej

Journal of the World Aquaculture Society > 53 > 2 > 367 - 383

The US catfish industry has undergone significant technological advancements in an attempt to achieve cost efficiencies. This study monitored the progress of the adoption of alternative and complementary technologies in the US catfish industry. A 2019–2020 multi‐state in‐person survey in Alabama, Arkansas, and Mississippi (n = 68), revealed increased adoption of intensively aerated ponds (6,315 ha)...

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An international field study of the ICD‐11 behavioural indicators for disorders of intellectual development

K. R. Lemay, C. S. Kogan, T. J. Rebello, J. W. Keeley, więcej

Journal of Intellectual Disability Research > 66 > 4 > 376 - 391

Background The World Health Organization (WHO) has approved the 11th Revision of the International Classification of Diseases (ICD‐11). A version of the ICD‐11 for Mental, Behavioural and Neurodevelopmental Disorders for use in clinical settings, called the Clinical Descriptions and Diagnostic Requirements (CDDR), has also been developed. The CDDR includes behavioural indicators (BIs) for assessing...

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Iron overload in inherited anaemias: why one size can't fit all

Noémi B. A. Roy

British Journal of Haematology > 196 > 2 > 266 - 267

artykuł

Introduced annuals mediate climate‐driven community change in Mediterranean prairies of the Pacific Northwest, USA

Paul B. Reed, Laurel E. Pfeifer‐Meister, Bitty A. Roy, Bart R. Johnson, więcej

Diversity and Distributions > 27 > 12 > 2584 - 2595

Aim How climate change will alter plant functional group composition is a critical question given the well‐recognized effects of plant functional groups on ecosystem services. While climate can have direct effects on different functional groups, indirect effects mediated through changes in biotic interactions have the potential to amplify or counteract direct climatic effects. As a result, identifying...

artykuł

Validation of a claims‐based algorithm for identifying non‐infectious pneumonitis in patients diagnosed with lung cancer

Shane S. Neibart, Daniella E. Portal, Jyoti Malhotra, Salma K. Jabbour, więcej

Pharmacoepidemiology and Drug Safety > 30 > 12 > 1624 - 1629

Purpose Non‐infectious pneumonitis (NIP) is a common complication of treatments for lung cancer. We know of no existing validated algorithm for identifying NIP in claims databases, limiting our ability to understand the morbidity and mortality of this toxicity in real‐world data. Methods Electronic health records (EHR), cancer registry, and administrative data from a National Cancer Institute‐designated...

artykuł

Association of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma species infection and organism load with cervicitis in north Indian population

A. Roy, R. Dadwal, R. Yadav, P. Singh, więcej

Letters in Applied Microbiology > 73 > 4 > 506 - 514

Cervicitis is predominantly caused by Neisseria gonorrhoeae and Chlamydia trachomatis, which accounts for almost half of all the cases of cervicitis. The role of newer organisms like Mycoplasma genitalium and Ureaplasma sp. and association of bacterial load with cervicitis are also not well established. So the study aimed to determine the relative frequency of these organisms and their load in association...

artykuł

Risk of HCC With Hepatitis B Viremia Among HIV/HBV‐Coinfected Persons in North America

H. Nina Kim, Craig W. Newcomb, Dena M. Carbonari, Jason A. Roy, więcej

Hepatology > 74 > 3 > 1190 - 1202

Background and Aims Chronic HBV is the predominant cause of HCC worldwide. Although HBV coinfection is common in HIV, the determinants of HCC in HIV/HBV coinfection are poorly characterized. We examined the predictors of HCC in a multicohort study of individuals coinfected with HIV/HBV. Approach and Results We included persons coinfected with HIV/HBV within 22 cohorts of the North American AIDS...

artykuł

The ‘black box’ of plant demography: how do seed type, climate and seed fungal communities affect grass seed germination?

Hunter C. Mackin, Katherine L. Shek, Tiffany E. Thornton, Kayla C. Evens, więcej

New Phytologist > 231 > 6 > 2319 - 2332

Demographic studies measure drivers of plant fecundity including seed production and survival, but few address both abiotic and biotic drivers of germination such as variation in climate among sites, population density, maternal plants, seed type and fungal pathogen abundance. We examined germination and microbial communities of seeds of Danthonia californica, which are either chasmogamous (external,...

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