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Islet cell autoantigen (ICA) 512 of type I diabetes is a receptor tyrosine phosphatase-like protein associated with the secretory granules of neurons and endocrine cells including insulin-secreting β-cells of the pancreas. Here we show that in a yeast two-hybrid assay its cytoplasmic domain binds β2-syntrophin, a modular adapter which in muscle cells interacts with members of the dystrophin family...
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