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Atopic dermatitis (AD) is a common inflammatory skin disease. In AD, cytokines such as interleukin (IL)-4 or interferon (IFN)-γ are considered to affect the disease status. Recently, human Vα24 + natural killer T (NKT) cells have been found to produce large amounts of IL-4 and IFN-γ. Thus there is a possibility that the proportion of Vα24 + NKT cells modifies the AD status. In this...
Vα14NK(natural killer) T cells play an important role in controlling tumors or in preventing autoimmunity in the murine system. Vα24NKT cells, the human counterpart of Vα14NKT cells, may contribute to controlling the progression of autoimmune diseases in humans. These findings show the possibility that ligand(s) for these NKT cells can control the above-mentioned pathological conditions. Specific...
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