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Amyloid precursor protein (APP) fragment containing amino acids 667–676, (APP 667–676 ), is a substrate for β-secretase which is responsible for generating amyloid β peptides. Conformational analysis of APP 667–676 peptide [Ac-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-NH 2 ] and the effect of substitution of Asp 672 with d-Asp and iso-l-Asp, studied for the first time,...
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