Search results for: Dong‐Seok Kim

Items from 1 to 20 out of 202 results

article

Ultra‐Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II

Ja Hye Kim, Ji‐Hyung Park, Junehawk Lee, Jung Woo Park, more

Annals of Neurology > 93 > 6 > 1082 - 1093

Objective Brain somatic mutations in mTOR pathway genes are a major genetic etiology of focal cortical dysplasia type II (FCDII). Despite a greater ability to detect low‐level somatic mutations in the brain by deep sequencing and analytics, about 40% of cases remain genetically unexplained. Methods We included 2 independent cohorts consisting of 21 patients with mutation‐negative FCDII without...

article

Experimental and simulation study of power performance improvement of GaN PIN betavoltaic cell

Dong‐Seok Kim, Young Jun Yoon, Jae Sang Lee, In Man Kang, more

International Journal of Energy Research > 45 > 12 > 17622 - 17630

We have demonstrated the gallium nitride (GaN)‐based betavoltaic (BV) cells with PN and PIN junction to investigate the relationship between the intrinsic GaN (i‐GaN) layer and power performance of BV cells. A short‐circuit current (I_SC) and an open‐circuit voltage (V_OC) of the fabricated BV cells were evaluated by using an electron‐beam (e‐beam) irradiation. The cell with PIN junction exhibited an...

article

Non–Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia

Hyun Yong Koh, Jaeson Jang, Sang Hyeon Ju, Ryunhee Kim, more

Annals of Neurology > 90 > 2 > 285 - 299

Objective Low‐level somatic mosaicism in the brain has been shown to be a major genetic cause of intractable focal epilepsy. However, how a relatively few mutation‐carrying neurons are able to induce epileptogenesis at the local network level remains poorly understood. Methods To probe the origin of epileptogenesis, we measured the excitability of neurons with MTOR mutation and nearby nonmutated...

article

Detection of Brain Somatic Mutations in Cerebrospinal Fluid from Refractory Epilepsy Patients

Seyeon Kim, Sara Baldassari, Nam Suk Sim, Mathilde Chipaux, more

Annals of Neurology > 89 > 6 > 1248 - 1252

Brain mosaic mutations are a major cause of refractory focal epilepsies with cortical malformations such as focal cortical dysplasia, hemimegalencephaly, malformation of cortical development with oligodendroglial hyperplasia in epilepsy, and ganglioglioma. Here, we collected cerebrospinal fluid (CSF) during epilepsy surgery to search for somatic variants in cell‐free DNA (cfDNA) using targeted droplet...

article

Cover Image

Young Jun Yoon, Jae Sang Lee, In Man Kang, Jung‐Hee Lee, more

International Journal of Energy Research > 45 > 1 > i - i

The cover image is based on the Special Issue Research Article Design and Optimization of GaN-based Betavoltaic Cell for Enhanced Output Power Density by Young Jun Yoon et al., https://doi.org/10.1002/er.5909.

article

Design and optimization of GaN‐based betavoltaic cell for enhanced output power density

Young Jun Yoon, Jae Sang Lee, In Man Kang, Jung‐Hee Lee, more

International Journal of Energy Research > 45 > 1 > 799 - 806

In this work, we designed and optimized a gallium nitride (GaN)‐based betavoltaic (BV) cell using an AlGaN back‐barrier layer and finger structure for improving the output power density. A short‐circuit current density (J_SC) and an open‐circuit voltage (V_OC) of the BV cells associated with an output power density were investigated by using electron‐beam (e‐beam) irradiation. The device with the Al...

article

Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Dong Seok Kim, Hyun Jeong Ju, Han Na Lee, In Hye Choi, more

The Journal of Dermatology > 47 > 7 > 749 - 754

Micropunch grafting is the simplest surgical intervention for refractory vitiligo but is tedious and time‐consuming. Therefore, we aimed to verify the efficacy and safety of dermal orientation grafting using motorized 0.5‐mm micropunch grafting for vitiligo. In a preliminary animal study, 12‐week‐old rats were used to observe the healing process after the transplantation of dermal orientation grafts...

article

Compact 4‐bit GaAs Ku‐band core chips for phased arrays

Dong‐Seok Kim, Kyung‐Whan Yeom

Microwave and Optical Technology Letters > 62 > 6 > 2289 - 2299

In this letter, we present an Rx core chip and a Tx core chip for Ku‐band phased arrays, which are designed and fabricated using the commercial 0.25‐μm GaAs pHEMT foundry service. Each of the Rx core chip and the Tx core chip has a 4‐bit phase shifter driven by an on‐chip serial‐to‐parallel (SPC) converter. The on‐chip SPC provides the serial interface with an external controller. The Rx core chip...

article

Precise detection of low-level somatic mutation in resected epilepsy brain tissue

Nam Suk Sim, Ara Ko, Woo Kyeong Kim, Se Hoon Kim, more

Acta Neuropathologica > 2019 > 138 > 6 > 901-912

Low-level somatic mutations have been shown to be the major genetic etiology of intractable epilepsy. The extents thereof, however, have yet to be systematically and accurately explored in a large cohort of resected epilepsy brain tissues. Moreover, clinically useful and precise analysis tools for detecting low-level somatic mutations from unmatched formalin-fixed paraffin-embedded (FFPE) brain samples,...

article

What is the concept of parental ‘emotional transference’ to children? A Walker and Avant concept analysis

Won‐Oak Oh, Insun Yeom, Dong‐Seok Kim

Scandinavian Journal of Caring Sciences > 33 > 1 > 34 - 42

Problem Human emotions come from relationships with others, and emotional states can be transferred to others through emotional transfer, leading people to experience identical emotions unconsciously. Emotional transference is not a new concept; however, no concept analysis has been performed on emotional transference from parents to children. Eligibility criteria A literature search was conducted...

article

Status and Utilization of the Beam Facility at KOMAC

Sunmog Yeo, Dong-Seok Kim, Chan Young Lee, Jae S. Lee, more

Journal of the Korean Physical Society > 2018 > 73 > 8 > 1029-1033

Korea Multi-Purpose Accelerator Complex (KOMAC) has been supporting a user beam service using 20- and 100-MeV proton beam facilities since the second half of 2013, and recently, beam facilities for radioisotope production and a low-flux proton beam have been built. A 100-MeV low-flux proton beam facility was constructed in 2007, which was due to the strong requirements of users in various R&D...

article

LGI3 promotes human keratinocyte differentiation via the Akt pathway

In Wook Kim, Hyo‐Soon Jeong, Nyoun Soo Kwon, Kwang Jin Baek, more

Experimental Dermatology > 27 > 11 > 1224 - 1229

Leucine‐rich repeat LGI family member 3 (LGI3), a member of the LGI family, is a secreted protein that is expressed not only in the brain and adipose tissues, but also in various skin cells. We previously reported that LGI3 was secreted after exposure to ultraviolet B and promoted the migration of HaCaT human keratinocytes. In the present study, we investigated whether LGI3 influences the differentiation...

article

A wearable hip-assist robot reduces the cardiopulmonary metabolic energy expenditure during stair ascent in elderly adults: a pilot cross-sectional study

Dong-Seok Kim, Hwang-Jae Lee, Su-Hyun Lee, Won Hyuk Chang, more

BMC Geriatrics > 2018 > 18 > 1 > 1-8

Background Stair ascent is one of the most important and challenging activities of daily living to maintain mobility and independence in elderly adults. Recently, various types of wearable walking assist robots have been developed to improve gait function and metabolic efficiency for elderly adults. Several studies have shown that walking assist robots can improve cardiopulmonary metabolic efficiency...

article

Treatment outcomes of radiotherapy for primary spinal cord glioma

Seo Hee Choi, Hong In Yoon, Seong Yi, Jong Won Park, more

Strahlentherapie und Onkologie > 2019 > 195 > 2 > 164-174

Purpose Spinal cord gliomas are rare, and there is no consensus on the optimal radiotherapy (RT) regimen. Herein, we investigated therapeutic outcomes in spinal cord gliomas to obtain clues for the optimal RT regimen. Methods We assessed 45 patients who received RT for primary spinal cord non-ependymoma gliomas between 2005 and 2017: 37 (82%) received postoperative RT, 6 (13%) underwent definitive...

article

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

Sang Min Park, Jae Seok Lim, Suresh Ramakrishina, Se Hoon Kim, more

Neuron > 2018 > 99 > 1 > 83-97.e7

Focal malformations of cortical development (FMCDs), including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are major etiologies of pediatric intractable epilepsies exhibiting cortical dyslamination. Brain somatic mutations in MTOR have recently been identified as a major genetic cause of FMCDs. However, the molecular mechanism by which these mutations lead to cortical dyslamination...

article

Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway

Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim, more

Molecular and Cellular Biochemistry > 2018 > 448 > 1-2 > 335-347

The current study was designed to investigate the therapeutic effects of Maresin 1 (MAR1) on atherosclerotic response. Human monocytes THP-1 and human umbilical vein endothelial cells (HUVECs) were used to investigate the effects of MAR1 on lipopolysaccharide (LPS)-induced inflammation and apoptosis. In this study, we found that MAR1 induces peroxisome proliferator-activated receptor alpha (PPARα)...

article

Neuropsychological impacts of indirect revascularization for pediatric moyamoya disease

WooHyun Kim, Eun-Young Lee, Seong-eun Park, Eun-Kyung Park, more

Child's Nervous System > 2018 > 34 > 6 > 1199-1206

Purpose Moyamoya disease (MMD) commonly leads to neurocognitive impairment. This study was carried out to show that temporal encephaloduroarteriosynangiosis (EDAS) has a positive neuropsychological impact on pediatric MMD patients. Methods Fifty-five participants diagnosed with MMD from 2008 to 2014 were included in this retrospective study. The mean age at the preoperative evaluation was 9.5 years...

article

Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas

Ji Hoon Phi, Ae Kyung Park, Semin Lee, Seung Ah Choi, more

Acta Neuropathologica > 2018 > 135 > 6 > 939-953

Despite great advances in understanding of molecular pathogenesis and achievement of a high cure rate in medulloblastoma, recurrent medulloblastomas are still dismal. Additionally, misidentification of secondary malignancies due to histological ambiguity leads to misdiagnosis and eventually to inappropriate treatment. Nevertheless, the genomic characteristics of recurrent medulloblastomas are poorly...

article

Poorly differentiated chordoma with loss of SMARCB1/INI1 expression in pediatric patients: A report of two cases and review of the literature

Yoon Jin Cha, Chang‐Ki Hong, Dong‐Seok Kim, Seung‐Koo Lee, more

Neuropathology > 38 > 1 > 47 - 53

Identification of loss of SMARCB1/INI1 expression in poorly differentiated (PD) chordoma in pediatric patients suggests that PD chordoma is an entity molecularly distinct from conventional chordoma or atypical teratoid/rhabdoid tumor, which is also characterized by loss of SMARCB1/INI1 expression by inactivating mutation of the SMARCB1/INI gene. So far, around 20 cases of pediatric PD chordoma with...

article

A highly-aligned lamellar structure of ice-templated LiFePO4 cathode for enhanced rate capability

Wook Ki Jung, Changyeon Baek, Joo-Hyung Kim, San Moon, more

Materials & Design > 2018 > 139 > C > 89-95

Ice-templating has been widely investigated in various energy-related fields owing to the simple and inexpensive process of this method which results highly-ordered lamellar structures. Lamellar structures offer larger active areas for ionic conductivity and a short mean free path of electrons. Here, an ice-templated LiFePO₄ cathode was introduced to achieve higher rate capability with a minimized...

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INFONA - science communication portal

Search results for: Dong‐Seok Kim

Ultra‐Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II

Experimental and simulation study of power performance improvement of GaN PIN betavoltaic cell

Non–Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia

Detection of Brain Somatic Mutations in Cerebrospinal Fluid from Refractory Epilepsy Patients

Cover Image

Design and optimization of GaN‐based betavoltaic cell for enhanced output power density

Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Compact 4‐bit GaAs Ku‐band core chips for phased arrays

Precise detection of low-level somatic mutation in resected epilepsy brain tissue

What is the concept of parental ‘emotional transference’ to children? A Walker and Avant concept analysis

Status and Utilization of the Beam Facility at KOMAC

LGI3 promotes human keratinocyte differentiation via the Akt pathway

A wearable hip-assist robot reduces the cardiopulmonary metabolic energy expenditure during stair ascent in elderly adults: a pilot cross-sectional study

Treatment outcomes of radiotherapy for primary spinal cord glioma

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway

Neuropsychological impacts of indirect revascularization for pediatric moyamoya disease

Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas

Poorly differentiated chordoma with loss of SMARCB1/INI1 expression in pediatric patients: A report of two cases and review of the literature

A highly-aligned lamellar structure of ice-templated LiFePO4 cathode for enhanced rate capability

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