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Abnormal white matter development in patients with tuberous sclerosis complex, a multisystem hamartomatous disorder caused by aberrant neural proliferation and axonal maturation, may be associated with poorer neurocognitive outcomes. The purpose of this study is to identify predictors of longitudinal changes in diffusion properties of white matter tracts in patients with tuberous sclerosis complex...
Imaging three-dimensional cerebellar connectivity using diffusion tractography is challenging because of the ubiquitous features of crossing axonal pathways within a folium as well as intersecting pathways from neighboring folia. We applied high-angular resolution diffusion imaging (HARDI) tractography to intact postmortem adult brainstem and cerebellum to examine the 3-dimensional white matter and...
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