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Background
When Wnt binds to the N‐terminal of Frizzled, a conformational change occurs in the C‐terminal of Frizzled, which binds to Dishevelled1 (Dvl1), a Wnt signaling component protein. When Dvl1 binds to the C‐terminal of Frizzled, the concentration of β‐catenin increases and it enters the nucleus to transmit cell proliferation signals. CXXC‐type zinc finger protein 5 (CXXC5) binds to the Frizzled...
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