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Sodium‐ion batteries (SIBs) have gradually become one of the most promising energy storage techniques in the current era of post‐lithium‐ion batteries. For anodes, transitional metal selenides (TMSe) based materials are welcomed choices , owing to relatively higher specific capacities and enriched redox active sites. Nevertheless, current bottlenecks are blamed for their poor intrinsic electronic...
Cancer and its metastasis/recurrence still threaten human health, despite various advanced treatments being employed. It is of great significance to develop simple drug formulations to enhance the efficacy and synergistic integration of various monotherapies. Herein, DMXAA, a vasodestructive agent with cGAS‐STING stimulation capacity, is integrated with polyethylene glycol grafted poly (lactic‐co‐glycolic)...
Heterojunctions are a promising class of materials for high‐efficiency bifunctional oxygen electrocatalysts in both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). However, the conventional theories fail to explain why many catalysts behave differently in ORR and OER, despite a reversible path (*O2⇋*OOH⇋*O⇋*OH). This study proposes the electron‐/hole‐rich catalytic center theory...
Nanoporous Materials
In article number 2300697, Li Sheng, Hong Xu, Cheng Wang, Xiangming He, and co‐workers provide a method (i.e. electrospinning) to convert sulfonated polymers into high‐performance lithium battery separators. The nanofibrous Nafion separator swelled in liquid electrolytes has in situ generated nanochannels, efficiently accelerating lithium ion transport.
Sulfonated polymers have long been used as proton‐conducting materials in fuel cells, and their ionic transport features are highly attractive for electrolytes in lithium‐ion/metal batteries (LIBs/LMBs). However, most studies are still based on a preconceived notion of using them directly as polymeric ionic carriers, which precludes exploring them as nanoporous media to construct efficient lithium...
The rise of flexible electronics calls for efficient microbatteries (MBs) with requirements in energy/power density, stability, and flexibility simultaneously. However, the ever‐reported flexible MBs only display progress around certain aspects of energy loading, reaction rate, and electrochemical stability, and it remains challenging to develop a micro‐power source with excellent comprehensive performance...
The cell membrane permeabilization ability of immune defense antimicrobial peptides (AMPs) is widely applied in biomedicine. Although the mechanisms of peptide–membrane interactions have been widely investigated, analyses at the molecular level are still lacking. Herein, the membrane‐specific action of a native AMP, As‐CATH4, is investigated using a single‐lipid tracking method in combination with...
Hepatic Ischemia‐Reperfusion Injury Management
Selenium‐doped carbon quantum dots (Se‐CQDs) with excellent anti‐oxidation capability protect hepatocytes from apoptosis by limiting damage from oxidative stress. Se‐CQDs‐lecithin nanoparticles are developed through a supramolecular self‐assembly mainly driven by noncovalent interactions, which effectively scavenge reactive oxygen species and inhibit...
Hepatic ischemia‐reperfusion injury (HIRI) is a critical complication after liver surgery that negatively affects surgical outcomes of patients with the end‐stage liver‐related disease. Reactive oxygen species (ROS) are responsible for the development of ischemia‐reperfusion injury and eventually lead to hepatic dysfunction. Selenium‐doped carbon quantum dots (Se‐CQDs) with an excellent redox‐responsive...
The in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F‐AuNSs) conjugated with antibodies and 64Cu radiolabels in vivo and in artificial lysosomal fluid ex vivo, is shown. The short‐term biodistribution of F‐AuNSs is driven by the route of systemic delivery (intravenous vs...
Anti‐icing coatings on outdoor infrastructures and transportations inevitably suffer from surface injuries, especially in extreme weather events (e.g., freezing weather or acid rain). The coating surface damage can result in anti‐icing performance loss or even icing promotion. The development of anti‐icing coatings that enables self‐healing in extreme conditions is highly desired but still challenging...
Despite their promised safety and mechanical flexibility, solvent‐free polymer electrolytes suffer from low Li‐ion conductivities due to poor dissociation of conducting salts and low Li+‐transference numbers due to Li+‐trapping by ether‐linkages. In this work, the authors found that oxygen vacancies carried by nanosized Al2O3 fillers preferentially promotes Li+‐conduction in poly(ethylene oxide) (PEO)...
Aqueous Zn‐MnO2 batteries using mild electrolyte show great potential in large‐scale energy storage (LSES) application, due to high safety and low cost. However, structure collapse of manganese oxides upon cycling caused by the conversion mechanism (e.g., from tunnel to layer structures for α‐, β‐, and γ‐phases) is one of the most urgent issues plaguing its practical applications. Herein, to avoid...
It is hard for current radionuclide therapy to render solid tumors desirable therapeutic efficacy owing to insufficient tumor‐targeted delivery of radionuclides and severe tumor hypoxia. In this study, a biocompatible hybrid protein nanoreactor composed of human serum albumin (HSA) and catalase (CAT) molecules is constructed via glutaraldehyde‐mediated crosslinking. The obtained HSA‐CAT nanoreactors...
Hypoxic microenvironments in the solid tumor play a negative role in radiotherapy. Holo‐lactoferrin (holo‐Lf) is a natural protein, which acts as a potential ligand of transferrin receptor (TfR). In this work, an anticancer drug, doxorubicin (Dox)‐loaded liposome‐holo‐Lf nanocomposites, is developed for tumor targeting and imaging guided combined radiochemotherapy. Dox‐loaded liposome‐holo‐Lf (Lf‐Liposome‐Dox)...
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor‐specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self‐assembly are coated with...
Although nanoparticle‐based drug delivery systems have been widely explored for tumor‐targeted delivery of radioisotope therapy (RIT), the hypoxia zones of tumors on one hand can hardly be reached by nanoparticles with relatively large sizes due to their limited intratumoral diffusion ability, on the other hand often exhibit hypoxia‐associated resistance to radiation‐induced cell damage. To improve...
Combining chemotherapy and radiotherapy (chemoradiotherapy) has been widely applied in many clinical practices, showing promises in enhancing therapeutic outcomes. Nontoxic nanocarriers that not only are able to deliver chemotherapeutics into tumors, but could also act as radiosensitizers to enhance radiotherapy would thus be of great interest in the development of chemoradiotherapies. To achieve...
Nanoparticles prefer to bind to a membrane with a surface coated by short or rigid ligands, as shown by computer simulations. To realize such a preferred configuration, the nanoparticle can spontaneously spin itself on the membrane surface, no matter what its initial orientation is.
The surprisingly spontaneous rotation behavior of nanoparticles whose surfaces are coated by two types of different ligands on the cell membrane surfaces are found by K. Yang, Y.‐Q. Ma, and co‐workers using computer simulations. As shown on page 1140 and illustrated in the lovely front cover of this special issue, such rotations of nanoparticles, and the final preferred configurations of nanoparticles...
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