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Urocortins (Ucns) injected peripherally decrease food intake and gastric emptying through peripheral CRF 2 receptors in rodents. However, whether Ucns influence circulating levels of the orexigenic and prokinetic hormone, ghrelin has been little investigated. We examined plasma levels of ghrelin and blood glucose after intravenous (iv) injection of Ucn 1, the CRF receptor subtype involved...
Brain corticotropin-releasing factor (CRF) acting on CRF receptor type 1 (CRF 1 ) is a main signaling pathway in the stress response. CRF is also produced in a variety of peripheral sites and acts locally as a proinflammatory mediator. We investigated CRF 1 mRNA expression in the human gastrointestinal tract, and localized CRF 1 immunoreactive cells in the colonic mucosa of...
Corticotropin releasing factor (CRF) is considered as the central driving force in the stress response and plays a key role in the pathogenesis of depression. CRF neurons have been identified to locate in most regions of the prefrontal cortex (PFC), a brain region that is highly associated with the control of emotion and cognition. However, little is known on the regulation of CRF in this region....
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