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This review elaborates the idea that organ regeneration derives from specific evolutionary histories of vertebrates. Regenerative ability depends on genomic regulation of genes specific to the life‐cycles that have differentially evolved in anamniotes and amniotes. In aquatic environments, where fish and amphibians live, one or multiple metamorphic transitions occur before the adult stage is reached...
Keratinization and the role of histidine in some species of fish and amphibians have been analyzed by immunocytochemistry and autoradiography. In cartilaginous and bony fishes, staining of acidic (AE1-positive) and basic (AE3-positive) keratins was strong and their distribution patterns were uniform in all epidermal layers. The AE2 antibody (for keratins K1 and K10 that are typical for keratinization)...
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