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AimsApelin is a specific endogenous ligand of orphan G protein‐coupled receptor APJ. This study was designed to determine the roles and mechanisms of apelin‐13 and APJ in paraventricular nucleus (PVN) in renal sympathetic nerve activity (RSNA), arginine vasopressin (AVP) release and mean arterial pressure (MAP) in spontaneously hypertensive rats (SHR).
MethodAcute experiment was carried out in 13‐week‐old...
AimsSalusin‐β in paraventricular nucleus (PVN) increases renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP), heart rate (HR) and arginine vasopressin (AVP) release in hypertensive rats but not in normal rats. The present study was designed to investigate the downstream molecular mechanism of salusin‐β in the PVN in hypertension.
MethodRenovascular hypertension was induced by two‐kidney,...
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