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Background:MAPT haplotypes are associated with PD, but their association with rapid eye movement sleep behavior disorder is unclear.
Objective: To study the role of MAPT variants in rapid eye movement sleep behavior disorder.
Methods: Two cohorts were included: (A) PD (n = 600), rapid eye movement sleep behavior disorder (n = 613) patients, and controls (n = 981); (B) dementia with Lewy bodies patients...
In the post-genome era, disease-relevant gene finding and prioritization have focused on genome-wide association studies and molecular interaction networks, due to their power in characterizing the functions of genes/proteins in genomics and network biology contexts. In this paper, we describe a simple yet generic computational framework based on protein interaction networks to perform and evaluate...
The identification of transcription factor binding sites in promoter sequences is an important problem, since it reveals information about the transcription regulation of genes. In this paper, a novel motif discovery method based on motif clustering and matching is proposed. Against a precompiled library of motifs which is represented by position weight matrices(PWMs), each L-mer in the dataset is...
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