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Background and Aims
Hepatocellular carcinoma (HCC) represents the third leading cause of cancer‐related mortality in the world. Over the past two decades, there has been minimal improvement in therapies as well as clinical outcomes for patients with Barcelona Clinic Liver Cancer (BCLC)‐B. These patients are treated with local interventions, including transarterial chemoembolization. Current methodologies...
Background and Aims
NAFLD has become the most common liver disease worldwide but lacks a well‐established pharmacological therapy. Here, we aimed to investigate the role of an E3 ligase SH3 domain‐containing ring finger 2 (SH3RF2) in NAFLD and to further explore the underlying mechanisms.
Methods and Results
In this study, we found that SH3RF2 was suppressed in the setting of NAFLD across mice,...