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Chronic myeloid leukemia (CML) is associated with overexpression of BCR-ABL1, a nonreceptor tyrosine kinase critical for malignant transformation. We investigated whether non-coding microRNAs (miRNAs) targeting BCR-ABL1 mRNA contribute to the pathogenesis of CML. Indeed, miR-30a targeted BCR-ABL1 and was underexpressed in bone marrow from CML patients. In K562 leukemia cells, overexpression of miR-30a...
MicroRNAs (miRNAs) were recently identified to play crucial roles in tumorigenesis processes. In present study, we explored the potential influence of miRNA-143 on several cellular biological processes related with lung cancer development in human bronchial epithelial cells 16-HBE. Chemosynthesis anti-miR-143 was used to down-regulate expression of miR-143. Cell proliferation was detected by methyl...
Resveratrol (3,4′,5-trihydroxystilbene, Res), a naturally occurring polyphenol, exhibits antioxidant, anti-inflammatory, potential chemopreventive and chemotherapeutic properties in preclinical studies. To further understand its potential clinical efficacy and safety, effect of Res at 10−9–10−4 mol/L on human embryonal kidney (HEK293) cell proliferation and its potential mechanism were investigated...
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