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Murine mGSTA4-4 is a glutathioneS-transferase with high activity and specificity for products of lipid peroxidation, including the cytotoxic 4-hydroxynonenal (4-HNE). Physiological relevance of this enzyme in the defense against effects of oxidative stress can be inferred from the above biochemical properties, and has been also directly demonstrated by usin vivo.The identification of residues responsible...
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