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Cap RNA methylations play important roles in the replication, evasion of host RNA sensor recognition, and pathogenesis. Coronaviruses possess both guanine N7‐ and 2′‐O‐ribose methyltransferases (N7‐MTase and 2′‐O‐MTase) encoded by nonstructural protein (nsp) 14 and nsp16/10 complex, respectively. In this study, we reconstituted the two‐step RNA methylations of N7‐MTase and 2′‐O‐MTase of severe acute...
Structures that facilitate fluid migration are common in sedimentary basins. We document several possible hydrothermal and/or volcanic vents located above a >157 km2, late Cretaceous volcanic field in the Great South Basin, offshore New Zealand. Three of the four vents are vertically stacked, suggesting episodic re‐use of the same fluid pathway between ca. 75 and 56 Ma. A palaeo‐pockmark dated...