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Emerging evidence has shown that other than glomerular endotheliosis, podocyte injury plays a key role in kidney dysfunction in preeclampsia (PE). Podocyte shedding has been demonstrated in patients with PE, and proteinuria is signature of podocyte injury. We previously found altered distribution and reduced expression of podocyte protein nephrin and podoplanin in shed podocytes in PE. However, the...
MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate gene expression and play important roles in various biological and pathological processes. Several miRNAs have been found to regulate endothelial cell (EC) function. Studies have shown that miR-203 plays an important role in the inflammatory response.The present study was designed to specifically investigate miR-203 in the regulation...
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