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Reduction of trifluoromethyl ketones by a crude alcohol dehydrogenase from Geotrichum affords (S)-trifluoromethyl carbinols in excellent ee, whereas the reduction of methyl ketones gives the corresponding alcohols of the opposite configuration in excellent ee.
When racemic 1-arylethanol is reacted with Geotrichum candidum IFO 5767 in water, (R)-1-arylethanol is obtained in high yield with excellent ee. It has been found that (S)-1-arylethanol is converted into the antipode via oxidation to the corresponding aryl methyl ketone and successive reduction of the ketone to the (R)-alcohol. Allyl alcohol as an additive enhances deracemization.
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