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Naloxegol, a peripherally acting μ‐opioid receptor antagonist, was recently approved in the United States for the treatment of opioid‐induced constipation. This study evaluated the effects of CYP3A inhibition and induction on the pharmacokinetics, safety, and tolerability of naloxegol. Separate open‐label, nonrandomized, fixed‐sequence, 3‐period, 3‐treatment, crossover studies of naloxegol (25 mg...
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