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Tolvaptan is a nonpeptide arginine vasopressin (AVP) V 2 -receptor antagonist and used in the treatment of heart failure, cirrhosis, syndrome of inappropriate antidiuretic hormone secretion or other high-volume capacity of hyponatremia. The metabolites of tolvaptan are mainly produced by CYP 3 A 4 , including two major compounds named DM-4103 and DM-4107. Herein, the chemical...
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