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miRNAs can play vital role in migration, invasion and proliferation in Squamous cell carcinoma of head and neck (SCCHN). In our study, we attempted to validate the expression and function of miR-1275 in SCCHN, and we also identified the mechanism by which miR-1275 affects migration, invasion and proliferation of SCCHN.Real-time polymerase chain reaction (RT-PCR) was employed to evaluate the expression...
The proliferation of pulmonary artery smooth muscle cells (PASMCs) plays a role in pulmonary vascular remodeling (PVR). Recently, it was shown that vascular smooth muscular cell phenotype modulation is important for their proliferation in other diseases. However, little is known about the role of human PASMC phenotype modulation in the proliferation induced by hypoxia and its molecular mechanism during...
The methylation status of the cytosines located on the 5 region of the pS2 gene have been investigated in two human breast cancer cell lines. The genomic sequencing method used is based on an oxydative deamination by NaHSO 3 of the unmethylated cytosines, but not 5-methylcytosine. Data obtained indicate that in the DNA extracted from the pS2-expressing cell line, MCF7, the CpG located...
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