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Microspheres prepared from hyaluronan esters (HYAFF®) have been evaluated as a novel delivery system for the vaginal administration of salmon calcitonin (sCT). HYAFF® microspheres containing sCT were prepared by a solvent extraction method. Spherical microspheres of about 10 mm in diameter with smooth surfaces were obtained. An HPLC method was developed for the determination of sCT incorporated into...
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