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Aims
Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed to the POCD occurrence through A1 adenosine receptor (A1AR) in aged mice.
Methods
We assessed cognitive function...
Aims
To clarify the correlation between chronic sleep restriction (CSR) and sporadic Alzheimer disease (AD), we determined in wild‐type mice the impact of CSR, on cognitive performance, beta‐amyloid (Aβ) peptides, and its feed‐forward regulators regarding AD pathogenesis.
Methods
Sixteen nine‐month‐old C57BL/6 male mice were equally divided into the CSR and control groups. CSR was achieved by application...
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