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The aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular and subpial membrane domains of astrocytes where it is concentrated. These membranes form the interface between the neuropil and the extracellular liquid spaces. The brain-selective deletion of the dystroglycan (DG) gene causes a disorganization of AQP4 on the astroglial endfeet. First, we analyzed the expression...
Morbidity and mortality in stroke are attributed to cerebral edema. To date, six aquaporins (AQPs) have been found in rat brains. Whereas studies have been focused on AQP1, -4 and -9, little is known about the expression of AQP3, -5 and -8. To clarify roles of AQP3, -5 and -8 in water movement, we examined the expression patterns of AQP3, -5 and -8 in ischemic brains from the rats with permanent middle...
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