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In heterologous expression systems, KCNE1 and KCNE2 each can associate with KCNQ1 and exert apparently opposite effects on its channel function. KCNQ1 and KCNE1 associate to form the slow delayed rectifier I Ks channels in the heart. Whether KCNE2 plays any role in I Ks function is not clear.The purpose of this study was to study whether KCNE2 can associate with KCNQ1 in the presence...
Y81C is a new long QT-5 (LQT5)-related KCNE1 mutation, which is located in the post-transmembrane domain (post-TMD) region in close proximity to three other LQT5 mutations (S74L, D76N, and W87R). We examine the effects of Y81C on the function and drug sensitivity of the slow delayed rectifier channel (I Ks ) formed by KCNE1 with pore-forming KCNQ1 subunits. We also infer a structural basis...
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