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Ikaros is important in the development and maintenance of the lymphoid system, functioning in part by associating with chromatin‐remodeling complexes. We have studied the functions of Ikaros in the transition from pre‐T cell to the CD4+CD8+ thymocyte using an Ikaros null CD4−CD8− mouse thymoma cell line (JE131). We demonstrate that this cell line carries a single functional TCR β gene rearrangement...
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