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With the development of bioinformatics and the nearing completion of the Human Genome Project, the task of optimizing the methods of gene sequencing is becoming more and more significant. Alternative splicing, which plays an important role in regulating gene expression, widespreads in eukaryote genes. So developing a better analysis algorithm for the recognition of alternative splicing sites is a...
Alternative splicing is the main mechanism expanding proteome diversity. Cryptic exon is an important alternative splicing form that is different from skipped exon in statistical characters. We introduce a process to identify the human cryptic exons in candidate ones. This method contains two steps performed by two classifiers based on the support vector machine (SVM). The first classifier distinguishes...
With the imminent completion of the Human Genome Project and the fast increase of many complete genomes of prokaryotes and eukaryotes, the task of organizing and understanding the generated sequence and structural data becomes more and more pressing and demands better and efficient analysis algorithms. Computational gene identification is an issue of obvious importance as a tool of identifying biologically...
In the process of training support vector machines (SVMs) by decomposition methods, working set selection is an important technique, and some exciting schemes were employed into this field. To improve working set selection, we propose a new model for working set selection in sequential minimal optimization (SMO) decomposition methods. In this model, it selects B as working set without reselection...
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