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In the post-genomic era, discovering relationships between genes and further constructing gene regulatory networks (GRNs) is an important problem in system biology. In case the GRNs model for a cell is known, we can simulate the gene expression to predict future states of the cell and discover new drugs based on the relationships in the GRNs. In this paper, our aim is to construct a better gene regulatory...
With the development of bioinformatics and the nearing completion of the Human Genome Project, the task of optimizing the methods of gene sequencing is becoming more and more significant. Alternative splicing, which plays an important role in regulating gene expression, widespreads in eukaryote genes. So developing a better analysis algorithm for the recognition of alternative splicing sites is a...
Alternative splicing is the main mechanism expanding proteome diversity. Cryptic exon is an important alternative splicing form that is different from skipped exon in statistical characters. We introduce a process to identify the human cryptic exons in candidate ones. This method contains two steps performed by two classifiers based on the support vector machine (SVM). The first classifier distinguishes...
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