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Heparan sulfate proteoglycan syndecan‐1, CD138, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. In the present study, we focused on the role of syndecan‐1 in human urothelial carcinoma of the urinary bladder. Silencing of syndecan‐1 by siRNA transfection down‐regulated transcriptional factor junB and the long isoform of FLICE‐inhibitory...
The fibroblast growth factor receptor (FGFR)‐3 gene encodes a receptor tyrosine kinase that is frequently mutated in non‐muscle invasive bladder cancer (NMIBC). A sensitive and quantitative assay using peptide nucleic acid‐mediated real‐time PCR was developed for detecting FGFR3 mutations in the urine samples and evaluated as a molecular marker for detecting intravesical recurrence of NMIBC in patients...
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