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A 16-channel implantable microelectrode array (MEA) was designed and fabricated by Micro-electromechanical Systems (MEMS) technology. Then the electrode sites were modified with platinum/graphene oxide nanocomposites (Pt-GO) by one-step electrochemical deposition and later handled by cyclic voltammetry reduction in phosphate buffer solution. Finally, a Nafion thin film was coated on the MEA surface...
In our central nervous system (CNS), glutamate is an excitatory neurotransmitter that can be accumulated remarkably by brain tissue. As is noticeable from previous studies, glutamate is somehow closely related with most ways of normal and abnormal cerebral activities. It was significant to monitor glutamate concentration changes in vivo real time. Therefore, we developed an enzyme-based microelectrode...
Dual-mode multielectrode recordings have become routine in rodent neuroscience research. However, robust and reliable application of acute, multielectrode recording methods in brain especially for in vivo research remains a challenge. In patients with Parkinson's disease (PD), the efficacy of L-dopa therapy depends on its ability to restore Dopamine (DA) neurotransmission in the striatum. In this...
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