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GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available.This study...
Background: Optimal adjuvant therapy following thrombolysis for acute myocardial infarction (AMI) remains an unresolved issue although intravenous unfractionated heparin (UFH) is commonly used. We compared the use of low molecular weight heparin (LMWH) with UFH following thrombolysis.Methods: Three hundred patients treated with thrombolysis for AMI were randomly assigned LMWH as enoxaparin (40 mg...
Background: Exercise and adequate nutrient intake are important for successful healthy aging. This study evaluates the relationship between aerobic capacity and nutrient intake in healthy elderly people.Methods: 260 healthy, community dwelling older (60-80 years) subjects (143 men, 117 women) performed the following battery of tests: 1) a fatigue-limited treadmill test with measurement of peak oxygen...
Angiotensin converting enzyme (ACE) gene polymorphism has been associated with increased levels of the enzyme as well as with acute myocardial infarction and other cardiovascular syndromes. However, the data on the association of DD genotype with hypertension are contradictory. This could be due to the multifactorial etiology of hypertension, sampling variation and incomplete adjustment for confounders...
The need for timely yet less costly scientific clinical information has led to the wider use of composite end point trials and meta analysis. To test the validity of these methods, we divided the Studies of Left Ventricular Dysfunction (SOLVD) Prevention Trial into randomly selected blocks, then conducted a meta analysis on the 2 outcome measures repeated 500 times. We then resampled the original...
Recent studies have suggested an increased risk of myocardial infarction (MI) in patients on calcium channel blockers (CCB). We evaluated the effect of CCB on fatal and non-fatal MI in 6797 patients with left ventricular dysfunction (LVD, EF =< 35%) in the Studies Of Left Ventricular Dysfunction (SOLVD).During 40 months average follow-up, fatal or non-fatal MI occurred in 11.5% of the 845 patients...
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