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The objectives of this study were to identify peptides that inhibit α-glucosidase using a quantitative structure-activity relationship (QSAR) screening method and a database of silkworm peptides. This study compared the docking characteristics of several peptides with high inhibitory activity against α-glucosidase and summarized the molecular mechanisms by which the silkworm peptides affected α-glucosidase...
GalNAc-transferase can catalyze the biosynthesis of O-linked oligosaccharides. The specificity of GalNAc-transferase is composed of nine amino acid residues denoted by R4, R3, R2, R1, R0, R1′, R2′, R3′, R4′. To predict whether the reducing monosaccharide will be covalently linked to the central residue R0(Ser or Thr), a new method based on feature selection has been proposed in our work. 277 nonapeptides...
The support vector machine approach was introduced to predict the β-turns in proteins. The overall self-consistency rate by the re-substitution test for the training or learning dataset reached 100%. Both the training dataset and independent testing dataset were taken from Chou [J. Pept. Res. 49 (1997) 120]. The success prediction rates by the jackknife test for the β-turn subset of 455 tetrapeptides...
Tight turns play an important role in globular proteins from both the structural and functional points of view. Of tight turns, β-turns and γ-turns have been extensively studied, but α-turns were little investigated. Recently, a systematic search for α-turns classified α-turns into nine different types according to their backbone trajectory features. In this paper, Support Vector Machines (SVMs),...
Zhou, A.-W., W.-X. Li, J. Guo and Y.-C. Du.Facilitation of AVP(4-8) on gene expression of BDNF and NGF in rat brain.Peptides 18(8) 1179-1187, 1997.-In situ hybridization and Northern blot assay were used to evaluate the effects of exogenous AVP(4-8) on the transcription of mRNAs for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) in the adult rat brain...
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