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Disrupted in schizophrenia 1 (DISC1) is an important hub protein, forming multimeric complexes by self‐association and interacting with a large number of synaptic and cytoskeletal molecules. The synaptic location of DISC1 in the adult brain suggests a role in synaptic plasticity, and indeed, a number of studies have discovered synaptic plasticity impairments in a variety of different DISC1 mutants...
Non‐technical summary The visual cortex and the somatosensory whisker ‘barrel’ cortex are widely studied model systems of experience‐dependent plasticity, which enables the brain to adapt to changes in the environment and is required for recovery in conditions such as stroke. It is known that presynaptic development of excitatory synapses in the cortex involves a decrease in the probability of neurotransmitter...
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