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We present an algorithm EcSymDock which optimized SymDock using Evolution couplings for better performance. SymDock is a protocol of Rosetta used to predict protein oligomer structure. Evolution Coupling (EC) is an optimized mutual information calculated by specific protein family MSA, it reveals certain contacts between residues. Today more and more researchers pay close attention to how to use ECs...
To predict protein structure based on Hydrophobic-Polar model (HP model) in two-dimensional space is called 2D HP protein folding problem. Ant Colony Optimization (ACO), which is inspired by the foraging behavior of ants, is a popular heuristic approach for solving combinatorial optimization problems. This paper presents a method of solving the 2D HP protein folding problem by parallel ACO algorithm...
DDRT-PCR is an effective and quick method to study differentially expressed genes on the same cells under differently physiological status and different stages. In this study fluorescence DDRT-PCR was used to compare mRNA of peripheral leucocytes of Common Carp stimulated and non-stimulated by mitogens (LPA, ConA and PHA) in different times such as 4 h, 12 h and 24 h. According to bioinformatic technology...
Bioinformatics is a dynamic research area in which a large number of algorithms and programs have been developed rapidly and independently without much consideration so far of the need for standardization. The lack of such common standards combined with unfriendly interfaces make it difficult for biologists to learn how to use these tools and to translate the data formats from one to another. Consequently,...
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