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Du-Zhong, rich in polyphenolic compounds such as lignans, phenolic acid, and flavonoids, is a kidney-tonifying herbal medicine with a long history of safe use for treatment of bone fractures and joint diseases in China. In the present study, we examined whether Du-Zhong cortex extract (DZCE) with graded doses exerted its preventive effects on estrogen deficiency-induced osteoporosis. Eighty 3-month-old...
Loss of subcutaneous fat, decreased muscle cross-sectional area (CSA) and increased muscle adiposity are related to declining physical function and disability in the elderly, but there is little information about the relationship of these tissue changes to hip fracture. Thus we have compared body composition measures in women with hip fractures to age-matched controls, using quantitative computed...
Previous reports have shown that bone loss was partially prevented by bipedal stance ''exercise'' following ovariectomy (ovx), and it was well documented that prostaglandin E2 (PGE 2 ) had an anabolic effect on the rat skeleton. The aim of this study was to determine whether lower doses of PGE 2 could prevent ovx-induced cancellous bone loss with the combination of bipedal stance exercise...
This study aimed to test whether bisphosphonates administration disturb fracture healing process of rat's femurs. 120 female SD rats of 6 weeks old were injected either Incadronate disodium (YM-175, Yamanouchi) a)10μg/kg, b)100μg/kg or vehicle 3times a week for 2weeks. Then right femurs were fractured and fixed with stainless wires. YM treatment stopped in P-a and P-b (pre-treatment), while it...
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