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The mechanistic target of rapamycin complex 1 (TORC1) senses nutrient availability to regulate eukaryotic anabolic metabolism. In response to limiting concentrations of amino acids, TORC1 kinase activity is inhibited through the GATOR‐1 complex. Mutations in DEPDC5, that encodes one of the components of the GATOR‐1 complex, have recently been associated with different forms of focal epilepsy. Here,...
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