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Objectives To study the binding of pranlukast to hRKIP and its regulatory role in the Raf1/MEK/ERK signal pathway. Results NMR and fluorescence experiments demonstrated hRKIP could bind pranlukast with a binding constant of 1016 mM−1. Residues (Y81, S109 and Y181) on the conserved ligand-binding pocket of hRKIP played a crucial role in binding pranlukast, and their mutations reduced the binding...
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