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To determine the efficacy and safety profile of the combination of cisplatin and 5-fluorouracil modulatedboth by methotrexate and leucovorin in metastatic/recurrent squamous cell carcinoma of the head and neck. Twenty-eight patients were treated with cisplatin 40 mg/m 2 /day continuous infusion for 24 hours on day 1;high-dose 5-fluorouracil 2,000 mg/m 2 /day and leucovorin 100 mg/m...
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