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A rapid and accurate LC method is described for simultaneous determination of pseudoephedrine hydrochloride (PSE), acetaminophen (AMP), dextromethorphen hydrobromide (DEX), and diphenhydramine hydrochloride (DPH) in a compound formulation. Chromatographic separation of the four drugs was achieved on a Hypersil CN column (150 mm 4.6 mm, 5 m particle) by use of a mobile phase comprising a mixture of...
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