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Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties. In recent years, the use of serum‐free media with brain‐derived growth factors (colony stimulating factor 1 receptor [CSF1R] ligands and TGF‐β1/2) have been favored for the maintenance of rodent microglia as they promote morphological features...
Cells of the adaptive and innate immune systems in the brain parenchyma and in the meningeal spaces contribute to physiologic functions and disease states in the central nervous system (CNS). Animal studies have demonstrated the involvement of immune constituents, along with major histocompatibility complex (MHC) molecules, in neural development and rare genetic disorders (e.g., colony stimulating...
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