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Purpose
Interleukin (IL)‐6 plays as a modulator for functions of lymphocytes. Significantly higher level of IL‐6 has been observed in primary orbital tissue cultures of thyroid‐associated ophthalmopathy (TAO) patients compared to those of non‐TAO patients. In the current study, we investigated the issue of whether of how orbital fibroblasts (OFs) from TAO patients significantly secret higher level...
Background DNA methylation (DNAm) levels can be used to predict the chronological age of tissues; however, the characteristics of DNAm age signatures in normal and cancer tissues are not well studied using multiple studies. Results We studied approximately 4000 normal and cancer samples with multiple tissue types from diverse studies, and using linear and nonlinear regression models identified reliable...
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