Search results for: Marta Fumagalli

Items from 1 to 19 out of 19 results

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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Stephen P. H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, more

British Journal of Pharmacology > 180 > S2 > S23 - S144

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug...

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, more

British Journal of Pharmacology > 178 > S1 > S27 - S156

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org),...

article

Regulation and signaling of the GPR17 receptor in oligodendroglial cells

Davide Lecca, Stefano Raffaele, Maria P. Abbracchio, Marta Fumagalli

Glia > 68 > 10 > 1957 - 1967

Remyelination, namely, the formation of new myelin sheaths around denuded axons, counteracts axonal degeneration and restores neuronal function. Considerable advances have been made in understanding this regenerative process that often fails in diseases like multiple sclerosis, leaving axons demyelinated and vulnerable to damage, thus contributing to disease progression. The identification of the...

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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Stephen P H Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, more

British Journal of Pharmacology > 176 > S1 > S21 - S141

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed...

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Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Marta Lombardi, Roberta Parolisi, Federica Scaroni, Elisabetta Bonfanti, more

Acta Neuropathologica > 2019 > 138 > 6 > 987-1012

Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which differentiate to myelin-forming cells, microglia participate in both myelin injury and remyelination during multiple sclerosis. However, the mode(s) of action of microglia in supporting or inhibiting myelin repair is still...

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How to reprogram microglia toward beneficial functions

Marta Fumagalli, Marta Lombardi, Pierre Gressens, Claudia Verderio

Glia > 66 > 12 > 2531 - 2549

Microglia, brain cells of nonneural origin, orchestrate the inflammatory response to diverse insults, including hypoxia/ischemia or maternal/fetal infection in the perinatal brain. Experimental studies have demonstrated the capacity of microglia to recognize pathogens or damaged cells activating a cytotoxic response that can exacerbate brain damage. However, microglia display an enormous plasticity...

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Differential local tissue permissiveness influences the final fate of GPR17‐expressing oligodendrocyte precursors in two distinct models of demyelination

Giusy T. Coppolino, Davide Marangon, Camilla Negri, Gianluca Menichetti, more

Glia > 66 > 5 > 1118 - 1130

Promoting remyelination is recognized as a novel strategy to foster repair in neurodegenerative demyelinating diseases, such as multiple sclerosis. In this respect, the receptor GPR17, recently emerged as a new target for remyelination, is expressed by early oligodendrocyte precursors (OPCs) and after a certain differentiation stage it has to be downregulated to allow progression to mature myelinating...

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CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

Marta Fumagalli, Davide Lecca, Maria P. Abbracchio

Neuropharmacology > 2016 > 104 > C > 82-93

Oligodendrocytes are the myelin-forming cells in the CNS. They enwrap axons, thus permitting fast impulse transmission and exerting trophic actions on neurons. Demyelination accompanied by neurological deficit is a rather frequent condition that is not only associated with multiple sclerosis but has been also recognized in several other neurodegenerative diseases, including brain trauma and stroke,...

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The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein‐coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

Marta Fumagalli, Elisabetta Bonfanti, Simona Daniele, Elisa Zappelli, more

Glia > 63 > 12 > 2327 - 2339

During oligodendrocyte precursor cell (OPC) differentiation, defective control of the membrane receptor GPR17 has been suggested to block cell maturation and impair remyelination under demyelinating conditions. After the immature oligodendrocyte stage, to enable cells to complete maturation, GPR17 is physiologically down‐regulated via phosphorylation/desensitization by G protein‐coupled receptor kinases...

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Does GRK–β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?

Simona Daniele, Maria Letizia Trincavelli, Marta Fumagalli, Elisa Zappelli, more

Cellular Signalling > 2014 > 26 > 6 > 1310-1325

During oligodendrocyte-precursor cell (OPC) differentiation program, an impairment in the regulatory mechanisms controlling GPR17 spatio-temporal expression and functional activity has been suggested to contribute to defective OPC maturation, a crucial event in the pathogenesis of multiple sclerosis. GRK–β arrestin machinery is the primary actor in the control of G-protein coupled receptor (GPCR)...

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UDP‐glucose enhances outward K⁺ currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors

Elisabetta Coppi, Giovanna Maraula, Marta Fumagalli, Paola Failli, more

Glia > 62 > 7 > 1155 - 1171

In the developing and mature central nervous system, NG2 expressing cells comprise a population of cycling oligodendrocyte progenitor cells (OPCs) that differentiate into mature, myelinating oligodendrocytes (OLGs). OPCs are also characterized by high motility and respond to injury by migrating into the lesioned area to support remyelination. K⁺ currents in OPCs are developmentally regulated during...

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Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury

Heike Franke, Chiara Parravicini, Davide Lecca, Elisa R. Zanier, more

Purinergic Signalling > 2013 > 9 > 3 > 451-462

Unveiling the mechanisms participating in the damage and repair of traumatic brain injury (TBI) is fundamental to develop new therapies. The P2Y-like GPR17 receptor has recently emerged as a sensor of damage and a key actor in lesion remodeling/repair in the rodent brain, but its role in humans is totally unknown. Here, we characterized GPR17 expression in brain specimens from seven intensive care...

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Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death

Davide Lecca, Stefania Ceruti, Marta Fumagalli, Maria P. Abbracchio

Purinergic Signalling > 2012 > 8 > 3 > 539-557

In the last decades, the discovery that glial cells do not only fill in the empty space among neurons or furnish them with trophic support but are rather essential participants to the various activities of the central and peripheral nervous system has fostered the search for the signalling pathways controlling their functions. Since the early 1990s, purines were foreseen as some of the most promising...

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The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage

Enrica Boda, Francesca Viganò, Patrizia Rosa, Marta Fumagalli, more

Glia > 59 > 12 > 1958 - 1973

NG2‐expressing cells comprise a population of cycling precursors that can exit the cell cycle and differentiate into mature oligodendrocytes. As a whole, they display heterogeneous properties and behaviors that remain unresolved at the molecular level, although partly interpretable as distinct maturation stages. To address this issue, we analyzed the expression of the GPR17 receptor, recently shown...

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Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures

Stefania Ceruti, Marta Fumagalli, Giovanni Villa, Claudia Verderio, more

Cell Calcium > 2008 > 43 > 6 > 576-590

Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X ₃ and P2Y receptors in primary mouse neuron-glia trigeminal cultures. Comparison...

article

CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors

Liaman Mamedova, Valérie Capra, Maria Rosa Accomazzo, Zhan-Guo Gao, more

Biochemical Pharmacology > 2005 > 71 > 1-2 > 115-125

Montelukast and pranlukast are orally active leukotriene receptor antagonists selective for the CysLT ₁ receptor. Conversely, the hP2Y _{1,2,4,6,11,12,13,14} receptors represent a large family of GPCRs responding to either adenine or uracil nucleotides, or to sugar-nucleotides. Montelukast and pranlukast were found to inhibit nucleotide-induced calcium mobilization in a human monocyte-macrophage...

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P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death

Cristina Banfi, Silvia Ferrario, Ombretta De Vincenti, Stefania Ceruti, more

Journal of Molecular and Cellular Cardiology > 2005 > 39 > 6 > 929-939

ATP acts as a neurotransmitter via seven P2X receptor-channels for Na ⁺ and Ca ²⁺ , and eight G-protein-coupled P2Y receptors. Despite evidence suggesting roles in human heart, the map of myocardial P2 receptors is incomplete, and their involvement in chronic heart failure (CHF) has never received adequate attention. In left myocardia from five to nine control and 5–12 CHF subjects...

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Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia

Fabio Bianco, Marta Fumagalli, Elena Pravettoni, Nadia D'Ambrosi, more

Brain Research Reviews > 2005 > 48 > 2 > 144-156

Microglial cells are the major cellular elements with immune function inside the CNS and play important roles in orchestrating inflammatory brain response to hypoxia and trauma. Although a complete knowledge of the endogenous factors leading to a prompt activation of microglia is not yet available, activation of P2 purinoreceptors by extracellular ATP has been indicated as a primary factor in microglial...

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Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y ₁ ₃ receptor

Marta Fumagalli, Letizia Trincavelli, Davide Lecca, Claudia Martini, more

Biochemical Pharmacology > 2004 > 68 > 1 > 113-124

The human P2Y ₁ ₃ receptor is a new receptor characterized by coupling to Gi, responsiveness to adenine di-phospho-nucleotides and blockade by the P2Y antagonist AR-C69931MX. The mouse P2Y ₁ ₃ ortholog has also been reported. Here we report, for the first time, the cloning of rat P2Y ₁ ₃ receptor, its pharmacological analysis and tissue distribution. Rat P2Y ...

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