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Background and Aims
Hepatic ischemia‐reperfusion (HIR) injury, a common clinical complication of liver transplantation and resection, affects patient prognosis. Ring finger protein 5 (RNF5) is an E3 ubiquitin ligase that plays important roles in endoplasmic reticulum stress, unfolded protein reactions, and inflammatory responses; however, its role in HIR is unclear.
Approach and Results
RNF5 expression...
Background and Aims
Hepatic ischemia–reperfusion injury (IRI) is a common complication of hepatectomy and liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator of G‐protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates the G‐protein and mitogen‐activated protein kinase (MAPK) signaling pathways. However, the...