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Background
Several studies have demonstrated that allergen‐specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD.
Methods
NC/Nga mice with induced AD‐like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae...
Background
Clinical presentation of nonsteroidal anti‐inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes.
Methods
We performed two‐step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving...
Peanut (PN) and tree nuts (TNs) are common causes of anaphylaxis in Western countries, but no information is available in Korea. To feature clinical characteristics of anaphylaxis caused by PN, TNs, and seeds, a retrospective medical record review was performed in 14 university hospitals in Korea (2009–2013). One hundred and twenty‐six cases were identified, with the mean age of 4.9 years. PN, walnut...
BackgroundAtopic dermatitis (AD) is exacerbated by psychological factors, such as stress. We previously reported that corticotrophin‐releasing hormone (CRH) treatment in AD patients decreased the proportion of IL‐10+ Tr1 cells, a subset of inducible regulatory T cells (Tregs). However, changes in the function of Tregs in response to CRH have yet to be studied.
MethodsWe analyzed the total proteins...
BackgroundBacterial flagellin, a Toll‐like receptor 5 agonist, is used as an adjuvant for immunomodulation. In this study, we aimed to evaluate the effect and its mechanism following intralymphatic administration of OVA‐flagellin (FlaB) mixture in the mouse model of allergic rhinitis.
Materials and MethodsBALB/c mice were sensitized with OVA and treated with an OVA‐FlaB mixture via intranasal, sublingual,...
BackgroundSince the recent establishment of a murine model of eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP), both the development of new drugs for treatment or prevention of eosinophilic CRSwNP and elucidation of their pathogenesis have been feasible. We investigated the therapeutic effects of resveratrol on CRSwNP and its mechanism of action using a murine model.
MethodsAfter induction...
To cite this article: Kim YH, Yang TY, Park C‐S, Ahn S‐H, Son BK, Kim JH, Lim DH, Jang TY. Anti‐IL‐33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy 2012; 67: 183–190.
AbstractBackground: Interleukin (IL)‐33 is involved in the Th2 immune response and could play an essential role in nasal allergy. Therefore, we aimed to investigate the therapeutic...
To cite this article: Hong S‐W, Kim M‐R, Lee E‐Y, Kim JH, Kim Y‐S, Jeon SG, Yang J‐M, Lee B‐J, Pyun B‐Y, Gho YS, Kim Y‐K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis‐like skin inflammation. Allergy 2011; 66: 351–359.
AbstractBackground: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although...
To cite this article: Shin T‐S, Kim JH, Kim Y‐S, Jeon SG, Zhu Z, Gho YS, Kim Y‐K. Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy 2010; 65: 1256–1265.
AbstractBackground: Previous evidence indicates that inhalation of lipopolysaccharide (LPS)‐containing with allergens induced mixed Th1 and Th17 cell responses in...
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