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The Toll/interleukin‐1 receptor (TIR) domains are key innate immune signalling modules. Here, we present the crystal structure of the TIR domain of human interleukin‐1 receptor 10 (IL‐1R10), also called interleukin 1 receptor accessory protein like 2. It is similar to that of IL‐1R9 (IL‐1RAPL1) but shows significant structural differences to those from Toll‐like receptors (TLRs) and the adaptor proteins...