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Imbalance of macrophage polarization characterized by an increase in the percentage of pro‐inflammatory M1 macrophages and a decrease in anti‐inflammatory M2 macrophages is considered a critical pathogenic mechanism of bisphosphonate‐related osteonecrosis of the jaws (BRONJ). Because high levels of Toll‐like receptor 4 (TLR4) mediates mitochondrial dyshomeostasis in Zoledronic Acid (ZA)‐treated M1...