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Aims/hypothesis SUR1(ABCC8)−/− mice lacking functional KATP channels are an appropriate model to test the significance of KATP channels in beta-cell function. We examined how this gene deletion interferes with stimulus-secretion coupling. We tested the influence of metabolic inhibition and galanin, whose mode of action is controversial. Methods Plasma membrane potential (Vm) and currents were measured...
Aims/hypothesis. SUR1(ABCC8)/ mice lacking functional KATP channels are an appropriate model to test the significance of KATP channels in beta-cell function. We examined how this gene deletion interferes with stimulus-secretion coupling. We tested the influence of metabolic inhibition and galanin, whose mode of action is controversial. Methods. Plasma membrane potential (Vm) and currents were measured...
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