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Lithium-pilocarpine-induced status epilepticus (SE) leads to the genesis of massive neuronal loss in adult rats and to a lesser extent in P21 rats. Neuronal damage occurs mainly via a process of necrosis in limbic forebrain, cerebral cortex, thalamus, and substantia nigra. It is not known, however, whether damage is the result of local excitotoxic hyperactivity or if leakage at the blood-brain barrier...
In the present study, we measured the effects of pentylenetetrazol (PTZ)-induced status epilepticus on the blood-brain barrier (BBB) permeability in rats at postnatal age 10 (P10) or 21 days (P21). Seizures were induced by the repetitive injection of subconvulsive doses of PTZ until the onset of status epilepticus characterized as the loss of quadruped posture. The BBB permeability changes to the...
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