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Recent data suggest that neuronal necrosis plays a prominent role in neuronal injury following status epilepticus (SE), even in the immature brain. We review the evidence that SE‐induced neuronal necrosis is an active form of death involving caspases and mitochondrial death factors. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL,...
The mechanism of status epilepticus-induced neuronal death in the immature brain is not fully understood. In the present study, we examined the contribution of caspases in our lithium–pilocarpine model of status epilepticus in 14 days old rat pups. In CA1, upregulation of caspase-8, but not caspase-9, preceded caspase-3 activation in morphologically necrotic cells. Pretreatment with a pan-caspase...
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