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Gabapentin (GBP) is a recently licenced antiepileptic drug whose mode of action remains to be fully elucidated. The following studies were designed to investigate the effects of GBP on several γ-aminobutyric acid (GABA) related neurochemical parameters in mouse brain. GBP (0–75 mg/kg) was administered by intraperitoneal injection either as a single dose or twice daily for 8 days. Animals were sacrificed...
1. The effects of repeated administration of the anticonvulsant compounds, vigabatrin (VGB) and tiagabine (TGB), on γ-aminobutyric acid (GABA) concentration and the activities of GABA-transaminase (GABA-T) and glutamic acid decarboxylase (GAD) were investigated in mouse cortex.2. VGB alone increased GABA levels and decreased GABA-T and GAD activities.3. TGB alone was essentially without effect.4....
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